Much like Saskatoon, Regina has a higher-than-average crime rate per capita, but unless you go out looking for trouble, nothing is likely to happen to you. The downtown area is quite safe, though you may run into the occasional panhandler or drunken person at night.
The two main neighbourhoods to avoid in Regina are the North Central and Heritage/Chinatown districts, which are located northwest and northeast of the downtown core, and where most of the crime and prostitution is concentrated.